網絡藥理學：中醫藥現代化征途上的破曉之光

在人類與疾病漫長而艱辛的搏鬥史中，醫學宛如一座不斷攀升的山峯，每一步的跨越都凝聚着無數智慧與探索的結晶。中醫藥，這座承載着華夏民族數千年健康密碼的古老寶庫，曾以其獨特的整體觀、辨證論治和方劑用藥，在歷史的長河中熠熠生輝，護佑着一代又一代人的安康。然而，當時代的車輪滾滾駛入現代科學的疆域，中醫藥卻遭遇了前所未有的挑戰，在還原、試錯的研究方法面前，生物系統的複雜和化學成分的繁雜，如同兩座難以逾越的大山，橫亙在中醫藥現代化的大道之上。

傳統困局：中醫藥探索的荊棘之路

中醫藥，宛如一位歷經滄桑卻底蘊深厚的智者，其理論體系猶如一張精密而宏大的網絡，將人體、疾病與藥物緊密相連。然而，傳統的中醫藥研究方法，卻像是在這張大網中摸索前行的行者，往往只能窺其一斑，而難見全貌。以往採用還原、試錯的方法，試圖將中醫藥的複雜體系拆解成一個個孤立的元素進行研究，就如同將一幅精美的畫卷裁剪成碎片，雖能看清每一片碎片的細節，卻失去了畫卷整體的韻味與意境。

據相關統計，在過去幾十年裏，運用傳統方法對中醫藥進行研究，雖然取得了一些成果，但成功率卻相對較低。在針對中藥複方的研究中，由於中藥複方往往包含多種成分，每種成分又可能作用於多個靶點，其作用機制錯綜複雜，使得研究過程困難重重。許多研究在耗費了大量的人力、物力和財力後，卻依然無法清晰地揭示中藥複方治療疾病的整體性機制，這無疑給中醫藥的現代化進程蒙上了一層厚厚的陰影。

網絡藥理學：新興學科的璀璨曙光

就在這迷茫與困境之中，一門新興學科——網絡藥理學，如同一道破曉的曙光，照亮了中醫藥現代化研究的漫漫征途。網絡藥理學，它融合了系統生物學、多向藥理學、計算生物學和網絡科學等多學科的知識，宛如一位技藝高超的工匠，巧妙地構建起“藥物—靶點—疾病”之間的複雜相互作用網絡。通過這張網絡，我們能夠從系統的層面深入理解藥物干預疾病的整體性機制，就像透過一扇明亮的窗戶，清晰地看到中醫藥這座寶庫內部的精妙結構。

網絡藥理學的出現，並非偶然。它是現代科學發展到一定階段的必然產物，也是中醫藥與現代科學相互碰撞、相互融合的結晶。它完美地契合了中醫藥整體性、系統性的核心哲學思想，爲理解中藥複方“多成分、多靶點、整體調節”的作用特點提供了強大的理論工具和研究範式。這就好比爲中醫藥研究量身定製了一把精準的鑰匙，能夠打開那扇通往真理的大門。

契合之美：傳統智慧與現代科學的交融

中醫藥的整體觀，強調人體是一個有機的整體，疾病的發生是人體內部環境與外部環境相互作用的結果，治療疾病需要從整體出發，綜合考慮各種因素。而網絡藥理學所構建的“藥物—靶點—疾病”相互作用網絡，正是從系統的層面揭示了藥物、靶點和疾病之間的複雜關係，與中醫藥的整體觀不謀而合。

以治療感冒的中藥複方爲例，傳統的研究方法可能只能關注到複方中某一種或幾種成分的抗菌、抗病毒作用，而忽略了其他成分在調節人體免疫功能、緩解症狀等方面的作用。而網絡藥理學則能夠全面分析複方中所有成分的作用靶點和信號通路，揭示出複方通過多成分、多靶點的協同作用，實現對感冒的整體調節。就像一支訓練有素的軍隊，各個成員分工明確、協同作戰，共同攻克敵人。據研究表明，運用網絡藥理學方法對中藥複方進行研究，能夠發現許多傳統方法難以發現的作用機制和潛在靶點，爲中醫藥的臨牀應用提供更加科學、準確的依據。

邁進之路：從經驗到證據與精準的跨越

網絡藥理學在中醫藥領域的廣泛應用，正在推動中醫藥從“經驗醫學”向“證據醫學”和“精準醫學”邁進。在過去，中醫藥的治療主要依靠醫生的臨牀經驗和患者的個體差異，缺乏科學、客觀的證據支持。而網絡藥理學的出現，爲中醫藥的研究提供了更加嚴謹、科學的方法和手段。通過對大量臨牀數據和實驗數據的分析和挖掘，我們能夠更加準確地瞭解中藥複方的療效和作用機制，爲中醫藥的臨牀應用提供更加可靠的證據。

同時，網絡藥理學還能夠根據患者的個體差異，制定個性化的治療方案，實現精準醫療。就像一位技藝精湛的裁縫，能夠根據每個人的身材特點和需求，量身定製出合身的衣服。例如，通過對患者的基因信息、代謝特徵等進行分析，結合網絡藥理學的研究成果，我們可以爲患者選擇最適合的中藥複方和治療方案，提高治療的針對性和有效性。據相關臨牀試驗顯示，採用網絡藥理學指導的精準治療方案，在治療某些慢性疾病方面，療效顯著提高，患者的生活質量也得到了明顯改善。

網絡藥理學，這位中醫藥現代化征程中的破曉使者，正以其獨特的魅力和強大的力量，引領着中醫藥走向更加輝煌的未來。它讓我們看到了傳統智慧與現代科學融合的無限可能，也讓我們對中醫藥的傳承與創新充滿了信心。讓我們攜手共進，藉助網絡藥理學的東風，讓中醫藥這顆璀璨的明珠在世界醫學的舞臺上綻放出更加耀眼的光芒。

參考文獻：《〈2025研究前沿〉發佈！“網絡藥理學在中醫藥現代化研究中的應用”入選 》·《中國中醫藥報》 2025·12·5

作者簡介：梁世傑 原首都醫科大學中醫門診部中醫主治醫師，本科學歷，從事中醫臨牀工作25年，積累了較豐富的臨牀經驗。師從首都醫科大學附屬北京中醫院肝病科主任醫師、著名老中醫陳勇，侍診多載，深得器重，盡得真傳！擅用“商湯經方分類療法”、專病專方結合“焦樹德學術思想”“關幼波十綱辨證”學術思想治療疑難雜症爲特色。現任北京樹德堂中醫研究院研究員，北京中醫藥薪火傳承新3+3工程—焦樹德門人（陳勇）傳承工作站研究員，國際易聯易學與養生專委會常務理事，中國中醫藥研究促進會焦樹德學術傳承專業委員會委員，中國藥文化研究會中醫藥慢病防治分會首批癌症領域入庫專家。榮獲2020年中國中醫藥研究促進會仲景醫學分會舉辦的第八屆醫聖仲景南陽論壇“經方名醫”榮譽稱號。2023年首屆京津冀“扁鵲杯”燕趙醫學研究主題徵文優秀獎獲得者。事蹟入選《當代科學家》雜誌、《中華英才》雜誌。

Network Pharmacology: A Dawn of Light on the Journey to Modernization of Chinese Medicine

In the long and painful history of mankind''s struggle with disease, medicine is like a mountain that continues to rise, and each step of leap is a crystal of innumerable wisdom and exploration. Traditional Chinese medicine, an ancient treasure trove that carries the health code of the Chinese nation for thousands of years, has stood a shining glow throughout history with its unique holistic view, dialectical healing and prescription medicine, which has protected the well-being of generations after generation. However, as the wheels of the age roll into the frontiers of modern science, However, traditional Chinese medicine has encountered unprecedented challenges. In the face of reduction, trial and error research methods, the complexity of biological systems and the complexity and complexity of chemical components stand like two insuperable mountains across the road of modernization of traditional Chinese Medicine.

Traditional dilemmas: the thorn road explored by Chinese medicine

Traditional Chinese medicine is like a wise man who has been through time but has deep roots, and its theoretical system is like another sophisticated and grand network that closely connects the human body, diseases and medicine. However, the traditional Chinese medicine research method is like a man who is groping through this great web, often only seeking a glimpse of it, but not seeing the whole picture. In the past, we used a reduction, trial and error method to try to dismantle the complex system of Chinese medicine into isolated elements for research. It is like cutting a beautiful painting into pieces. Although we can see the details of each piece, we lose the overall flavor and sentiment of the painting.

According to relevant statistics, in the past few decades, research on Chinese medicine using traditional methods has achieved some results, but the success rate has been relatively low. In the study of Chinese medicine compounds, because Chinese medicine combinations often contain multiple components, and each component may act on multiple targets, the mechanism of action is intricate, making the research process difficult. Many studies, after spending a lot of human, material and financial resources, still cannot clearly reveal the holistic mechanism of traditional Chinese medicine compounds to treat diseases, which undoubtedly cast a thick shadow on the modernization process of traditional medicine.

Network Pharmacology: a bright dawn in an emerging discipline

In the midst of this confusion and dilemma, an emerging discipline - network pharmacology - lit up the long journey of modern Chinese medicine research like a dawn dawn. Network pharmacology, which combines the knowledge of systems biology, multidirectional pharmacology, computational biology, and network science, is like a skilled craftsman who deftly constructs complex networks of interactions between drugs-target-diseases. Through this network, we are able to gain a deep systemic understanding of the holistic mechanisms of drug intervention in disease, as if through a bright window, we can clearly see the wonderful structure within this treasure trove of Chinese medicine.

The emergence of network pharmacology is not an accident. It is an inevitable product of the development of modern science to a certain stage, and also a crystallization of the collision and integration of traditional Chinese medicine and modern science. It perfectly meets the core philosophical idea of holistic and systematic traditional Chinese medicine, and provides a powerful theoretical tool and research paradigm for understanding the role characteristics of traditional Chinese herbal remedies with "many components, multiple targets, and holistic regulation." It''s like tailoring a precise key to Chinese medicine research that can open the door to the truth.

The Beauty of Confection: The Convergence of Traditional Wisdom and Modern Science

The holistic view of traditional Chinese medicine emphasizes that the human body is an organic whole, that the occurrence of diseases is the result of the interaction between the internal environment and the external environment of the human body, and that the treatment of diseases requires a holistic approach and comprehensive consideration of various factors. The network of "drug-target-disease" interactions constructed by network pharmacology reveals the complex relationship between drugs, targets and diseases from a systematic level, which is consistent with the holistic view of Chinese medicine.

Taking the Chinese medicine compound for cold treatment as an example, traditional research methods may only focus on the antibacterial and antiviral effects of one or several components of the compound, and ignore the role of other components in regulating human immune function and relieving symptoms. Network pharmacology can comprehensively analyze the action targets and signaling pathways of all components in the compound, revealing that the compound achieves the overall regulation of cold through the synergy of multiple components and multiple targets. Like a well-trained army, each member has a clear division of labor and works together to conquer the enemy. According to research, the study of traditional Chinese medicine compounds using network pharmacology methods can discover many mechanisms of action and potential targets that are difficult to discover with traditional methods, providing a more scientific and accurate basis for the clinical application of traditional medicine.

The Road to Progress: a leap from experience to evidence and precision

The extensive application of network pharmacology in the field of Chinese medicine is driving the progress of Chinese medicine from "empirical medicine" to "evidence medicine" and "precision medicine." In the past, the treatment of traditional Chinese medicine relied mainly on the clinical experience of doctors and the individual differences of patients, which lacked scientific, objective evidence support. The emergence of network pharmacology has provided a more rigorous and scientific method and means for the study of Chinese medicine. Through the analysis and mining of large amounts of clinical and experimental data, we can more accurately understand the efficacy and mechanism of action of traditional Chinese medicine compounds, and provide more reliable evidence for the clinical application of traditional medicine.

At the same time, network pharmacology can also formulate a personalized treatment plan based on the individual differences of patients, achieving precision medicine. It is like a skilled tailor who can tailor a suit to suit each person''s body characteristics and needs.For example, by analyzing a patient’s genetic information and metabolic characteristics, and combining this with the findings of network pharmacology research, we can select the most suitable traditional Chinese medicine formula and treatment plan for the patient, thereby enhancing the targeted and effective nature of the treatment.According to relevant clinical trials, precision treatment guided by network pharmacology has significantly improved the efficacy of certain chronic diseases, and the quality of life of patients has also improved.

Network Pharmacology, the dawn messenger in the modernization of Chinese medicine, is leading the Chinese medicine to a brighter future with its unique charm and powerful power. It shows us the limitless possibility of integrating traditional wisdom with modern science, and gives us confidence in the inheritance and innovation of traditional Chinese medicine. Let us work together to harness the winds of network pharmacology to make the brilliant pearl of Chinese medicine shine even brighter on the stage of world medicine.

References: "The Frontiers of Research 2025" is released!"Application of Network Pharmacology in Study of Modernization of Chinese Medicine" was selected > > China Journal of Chinese Medicine December 5, 2025

Author Profile: Liang Shi-jie was a chief physician of traditional Chinese medicine at the Traditional Chinese Medicine Outpatient Clinic of Capital Medical University. He holds a bachelor’s degree and has been involved in clinical work in traditional Chinese medicine for 25 years, accumulating extensive clinical experience. He studied under Chen Yong, a renowned senior traditional Chinese medicine practitioner at the Hepatology Department of Beijing Hospital Affiliated to Capital Medical University. Over the years, he gained great respect and acquired genuine expertise. He specializes in using the “Shang Tang Classic Classification Therapy” and combining specific treatments for specific diseases with the “Jiao Shu-de Academic Thought” and the “Guan You-bo Ten-Principle Diagnosis” approach to treat complex and rare conditions. Currently, he serves as a researcher at the Beijing Shu-de-Tang Traditional Chinese Medicine Research Institute and a researcher at the Jia Shu-de Disciples (Chen Yong) Heritage Workstation of the Beijing New 3+3 Project for the Succession of Traditional Chinese Medicine. He is a member of the Executive Committee of the International Yi-lian Yi-xue and Health Preservation Committee, a member of the Jia Shu-de Academic Heritage Committee of the China Research Promotion Association for Traditional Chinese Medicine, and a first-batch expert in the cancer field of the China Cultural Research Association for Traditional Chinese Medicine’s Prevention of Chronic Diseases. He was awarded the title of “Expert in Classic Prescriptions” at the Eighth Symposium of the Medicine Saint Zhang Zhongjing of Nanyang, organized by the China Research Promotion Association of Traditional Chinese Medicine in 2020. In 2023, he won the Excellence Award in the First Beijing-Tianjin-Hebei “Bian Que Cup” Symposium on Yan-Zhao Medical Research. His achievements have been featured in the magazines “Contemporary Scientists” and “China’s Elite”.